Exhibit 15.1
CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
We consent to the incorporation by reference in the following Registration Statements:
| (1) | Amendment No. 1 to the Registration Statement (Form F-3 No. 333-276000) of Can-Fite BioPharma Ltd., |
| (2) | Registration Statement (Form F-3 No. 333-274316) of Can-Fite BioPharma Ltd., |
| (3) | Registration Statement (Form F-3 No. 333-262055) of Can-Fite BioPharma Ltd., |
| (4) | Registration Statement (Form F-3 No. 333-281872) of Can-Fite BioPharma Ltd., |
| (5) | Registration Statement (Form S-8 No. 333-227753) pertaining to the 2003 Israeli Share Option Plan and 2013 Global Incentive Option Scheme of Can-Fite BioPharma Ltd. |
| (6) | Registration Statement (Form S-8 No. 333-271384) pertaining to the 2013 Global Incentive Option Scheme of Can-Fite BioPharma Ltd., and |
| (7) | Registration Statement (Form S-8 No. 333-278525) pertaining to the 2023 Option Plan of Can-Fite BioPharma Ltd.; |
of our report dated March 26, 2026, with respect to the consolidated financial statements of Can-Fite BioPharma Ltd. included in this Annual Report (Form 20-F) of Can-Fite BioPharma Ltd. for the year ended December 31, 2025.
| /s/ Kost Forer Gabbay & Kasierer | |
| A Member of EY Global | |
| Tel-Aviv, Israel | |
| March 26, 2026 |