Exhibit 15.1
CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
We consent to the incorporation by reference in the following Registration Statements:
| 1. | Registration Statement (Form F-3 No. 333-236064) of Can-Fite BioPharma Ltd., |
| 2. | Registration Statement (Form F-3 No. 333-276000) of Can-Fite BioPharma Ltd., |
| 3. | Registration Statement (Form F-3 No. 333-274316) of Can-Fite BioPharma Ltd., |
| 4. | Registration Statement (Form F-3 No. 333-262055) of Can-Fite BioPharma Ltd., |
| 5. | Registration Statement (Form F-3 No. 333-281872) of Can-Fite BioPharma Ltd., |
| 6. | Registration Statement (Form S-8 No. 333-271384) pertaining to the 2013 Global Incentive Option Scheme of Can-Fite BioPharma Ltd. |
| 7. | Registration Statement (Form S-8 No. 333-227753) pertaining to the 2003 Israeli Share Option Plan and 2013 Global Incentive Option Scheme of Can-Fite BioPharma Ltd. |
| 8. | Registration Statement (Form S-8 No. 333-278525) pertaining to the 2023 Option Plan of Can-Fite BioPharma Ltd. |
of our report dated April 14, 2025, with respect to the consolidated financial statements of Can-Fite BioPharma Ltd. included in this Annual Report (Form 20-F) of Can-Fite BioPharma Ltd. for the year ended December 31, 2024.
| Tel-Aviv, Israel | /s/ Kost Forer Gabbay & Kasierer |
| April 14, 2025 | A Member of EY Global |