Can-Fite: Positive New Data from it’s
Phase III Psoriasis Study will be Presented
Today at an Industry Expert Summit in Boston
|●||The Summit will host industry drug development experts, all in the dermatology arena, who will present their technologies, exchange views and look at potential collaborations and partnerships.|
|●||Phase III COMFORT study successfully met its primary efficacy endpoint with Piclidenoson showing a safety profile similar to placebo and better tolerated than Otezla® at the 6th Annual Dermatology Drug Development Summit for Inflammatory Skin Diseases in Boston|
|●||Piclidenoson set for upcoming pivotal Phase III registration trial|
PETACH TIKVA, Israel, November 2, 2022 -- Can-Fite BioPharma Ltd. (NYSE American: CANF) (TASE: CFBI), a biotechnology company advancing a pipeline of proprietary small molecule drugs that address inflammatory, cancer and liver diseases, announced today the Company’s CEO, Dr. Pnina Fishman, will deliver a presentation titled “Piclidenoson for the Treatment of Psoriasis: Clinical Development and Mechanism of Drug Action” at the 6th Annual Dermatology Drug Development Summit for Inflammatory Skin Diseases on November 2, 2022. The Summit takes place in Boston from November 1-3, 2022.
COMFORT™, a Phase III, multicenter, randomized, placebo- and active-controlled, double-blind study assessed the efficacy and safety of Piclidenoson in more than 400 adults with moderate to severe plaque psoriasis. Piclidenoson demonstrated a statistically significant improvement when compared with placebo as measured by the Psoriasis Area and Severity Index (PASI) 75 response and the Physician Global Assessment (PGA) response index calculated based on the Erythema + Infiltration + Desquamation. The study further showed that in patients with severe disease, Piclidenoson’s efficacy is similar to Otezla®, currently the top selling oral psoriasis drug. Piclidenoson’s safety profile in the study was similar to placebo and it was better tolerated than Otezla®.
The Summit will host industry drug development experts, all in the dermatology arena, who will present their technologies, exchange views and look at potential collaboration and partnerships.
Piclidenoson is a novel, first-in-class, A3 adenosine receptor agonist (A3AR) small molecule, orally bioavailable drug with an excellent safety profile demonstrating evidence of efficacy in Phase II clinical studies. The drug’s mechanism of action entails inhibition of the inflammatory cytokines interleukin 17 and 23 (IL-17 and IL-23) and the induction of apoptosis of patients’ skin cell keratinocytes involved with the disease pathogenicity.
About Can-Fite BioPharma Ltd.
Can-Fite BioPharma Ltd. (NYSE American: CANF) (TASE: CFBI) is an advanced clinical stage drug development Company with a platform technology that is designed to address multi-billion dollar markets in the treatment of cancer, liver, and inflammatory disease. The Company’s lead drug candidate, Piclidenoson recently reported topline results in a Phase III trial for psoriasis. Can-Fite’s liver drug, Namodenoson, is being evaluated in a Phase IIb trial for the treatment of non-alcoholic steatohepatitis (NASH), and enrollment is expected to commence in a Phase III trial for hepatocellular carcinoma (HCC), the most common form of liver cancer. Namodenoson has been granted Orphan Drug Designation in the U.S. and Europe and Fast Track Designation as a second line treatment for HCC by the U.S. Food and Drug Administration. Namodenoson has also shown proof of concept to potentially treat other cancers including colon, prostate, and melanoma. CF602, the Company’s third drug candidate, has shown efficacy in the treatment of erectile dysfunction. These drugs have an excellent safety profile with experience in over 1,500 patients in clinical studies to date. For more information please visit: www.can-fite.com.
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