Exhibit 15.1




We consent to the incorporation by reference in the following Registration Statements:           


1.Registration Statement (Form F-3 No. 333-195124) of Can-Fite Biopharma Ltd.,
2.Registration Statement (Form F-3 No. 333-236064) of Can-Fite Biopharma Ltd.,
3.Registration Statement (Form F-3 No. 333-209037) of Can-Fite Biopharma Ltd.,
4.Registration Statement (Form F-3 No. 333-249063) of Can-Fite Biopharma Ltd.,
5.Registration Statement (Form F-3 No. 333-262055) of Can-Fite Biopharma Ltd., and
6.Registration Statement (Form S-8 No. 333-227753) pertaining to the 2003 Israeli Share Option Plan and 2013 Global Incentive Option Scheme of Can-Fite Biopharma Ltd.;


of our report dated March 24, 2022, with respect to the consolidated financial statements of Can-Fite Biopharma Ltd. included in this Annual Report (Form 20-F) of Can-Fite Biopharma Ltd. for the year ended December 31, 2021.


Tel-Aviv, Israel   /s/  Kost Forer Gabbay & Kasierer
March 24, 2022   A Member of Ernst & Young Global