The anti-NASH Effect of Namodenoson will be Presented at the International Conference on Fatty Liver in Berlin
|●||The podium presentation will be in a session of ‘Selected Abstracts of Excellence’|
|●||Top line data from Can-Fite Phase II study of Namodenoson in the treatment of NAFLD and NASH expected H2 2019|
|●||Preclinical data show improved liver function, anti-inflammatory, anti-fibrotic, anti-steatotic effects|
PETACH TIKVA, Israel, May 23, 2019 -- Can-Fite BioPharma Ltd. (NYSE American: CANF) (TASE:CFBI), a biotechnology company with a pipeline of proprietary small molecule drugs that address cancer, liver and inflammatory diseases, announced today that it has been selected for a podium presentation in a session of ‘Selected Abstracts of Excellence’ titled, “Namodenoson anti-NAFLD/NASH Activity is Mediated via De-regulation of the Wnt/β-catenin Pathway” at the 2nd Annual International Conference on Fatty Liver (ICFL 2019) in Berlin, Germany which takes place on June 27-29, 2019. Can-Fite CEO Dr. Pnina Fishman will deliver the presentation at 15:50 on June 28, 2019.
ICFL 2019 is focused on the clinical needs and best practices for diagnosing and treating fatty liver disease to address the challenges and long-term effects of this disease. ICFL 2019 will feature leading experts across the relevant fields to educate and foster knowledge exchange.
“We look forward to presenting data on Namodenoson at this gathering of the world’s thought leaders on fatty liver disease. Our compelling preclinical findings with NASH experimental models as well as our Phase II study design will be discussed. Top line results from our Phase II study in nonalcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are expected in the second half of 2019,” stated Dr. Fishman.
The Phase II NASH study is currently ongoing in Israel and aimed at the enrollment of 60 patients who suffer from NAFLD/NASH with evidence of active inflammation. The patients are treated twice daily with 12.5 or 25 mg of oral Namodenoson vs. placebo for 12 weeks. The primary end points of the Phase II study have been recently amended and include the anti-inflammatory effect of the drug, as determined by ALT blood levels, and the percentage of liver fat, as measured by MRI-PDFF (proton density fat fraction). The Company anticipates the data release in the second half of 2019.
Namodenoson is a small orally bioavailable drug that binds with high affinity and selectivity to the A3 adenosine receptor (A3AR). Namodenoson is being evaluated as a second line treatment for hepatocellular carcinoma, with a recently completed Phase II trial and planned Phase III trial in this indication. The drug is currently in an ongoing Phase II trial as a treatment for non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). A3AR is highly expressed in diseased cells whereas low expression is found in normal cells. This differential effect accounts for the excellent safety profile of the drug.
About Can-Fite BioPharma Ltd.
Can-Fite BioPharma Ltd. (NYSE American: CANF) (TASE: CFBI) is an advanced clinical stage drug development Company with a platform technology that is designed to address multi-billion dollar markets in the treatment of cancer, inflammatory disease and sexual dysfunction. The Company’s lead drug candidate, Piclidenoson, is currently in Phase III trials for rheumatoid arthritis and psoriasis. Can-Fite’s liver cancer drug, Namodenoson, recently completed a Phase II trial for hepatocellular carcinoma (HCC), the most common form of liver cancer, and is in a Phase II trial for the treatment of non-alcoholic steatohepatitis (NASH). Namodenoson has been granted Orphan Drug Designation in the U.S. and Europe and Fast Track Designation as a second line treatment for HCC by the U.S. Food and Drug Administration. Namodenoson has also shown proof of concept to potentially treat other cancers including colon, prostate, and melanoma. CF602, the Company’s third drug candidate, has shown efficacy in the treatment of erectile dysfunction in preclinical studies and the Company is investigating additional compounds, targeting A3AR, for the treatment of sexual dysfunction. These drugs have an excellent safety profile with experience in over 1,000 patients in clinical studies to date. For more information please visit: www.can-fite.com.
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